MEMBER

Hideki Ueno M.D., Ph.D.

Hideki Ueno M.D., Ph.D.

Professor

Education:

  • 1992 M.D.

    Faculty of Medicine, Kyoto University, Kyoto, Japan

  • 2001 Ph.D.

    Graduate School of Medicine, Kyoto University, Kyoto, Japan

Professional Appointments:

  • 2001

    Post-Doctoral Fellow. Baylor Institute for Immunology Research (BIIR), Dallas, TX, USA

  • 2004

    Assistant Investigator. BIIR

  • 2009

    Associate Investigator. BIIR

  • 2011- 2016

    Investigator. BIIR

  • 2016.4

    Professor. Global Health and Emerging Pathogens Institute, Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

  • 2019.7

    Professor. Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan (Cross-appointment with Mount Sinai until 2021.3)

  • 2021.4

    Full-time Professor. Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

I have more than 25 years of experience in human immunology research. At Baylor Immunology Research Institute, I started my research carrier with the focus on cancer vaccine development using dendritic cells (DCs), and immunomonitoring on cancer antigen-specific T cells in patients who underwent DC-based vaccinations. I have conducted basic and clinical research on human dendritic cell subsets and human follicular helper T (Tfh) cells. Major achievements include: determination of functional differences in human skin DC subsets; discovery of human Tfh cell subsets; elucidation of the involvement of Tfh cell subsets in autoimmune diseases; establishment of human Tfh cell differentiation pathways; and elucidation of the involvement of Tfh cells in antibody production after seasonal influenza vaccination.

I returned to Kyoto in 2019, 20 years after my Ph.D. Once again, I fell in love with the excellence of Kyoto University and the students, and the beauty of the city of Kyoto. A big fan of 70's and 80's culture, including Japanese vintage audio like Sansui, Denon, Yamaha, and Trio. U.S. citizen.

Hiroyuki Yoshitomi M.D., Ph.D.

Hiroyuki Yoshitomi M.D., Ph.D.

Associate Professor

  • 1995 M.D.

    Faculty of Medicine, Kyoto University, Kyoto, Japan. Joined the Department of Orthopaedic surgery.

  • 2005 Ph.D.

    Graduate School of Medicine, Kyoto University, Kyoto, Japan. Since receiving my PhD, I have been involved in rheumatoid arthritis research in humans.

  • 2012

    Associate Professor. Center for Innovation in Immunoregulative Technology and Therapeutics

  • 2015

    Associate Professor. Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

  • 2016

    Associate Professor. iPS Cell Research Institute (concurrent post),

  • 2019.7

    Associate Professor. Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Major achievements include the identification of CXCL13-producing CD4+ T cells in rheumatoid arthritis synovium, which population is now established as peripheral helper T (Tph) cells that are involved in a variety of diseases. I continue to conduct basic human immunology research using human specimens, including rheumatoid arthritis.

I spend my weekends trail running in the mountains to refresh my mind and body, and I sometimes show up at the lab in my running clothes.

Yoshitaka Honda M.D., Ph.D.

Yoshitaka Honda M.D., Ph.D.

Program-Specific Assistant Professor

  • 2009 M.D.

    Faculty of Medicine, Kyoto University, Kyoto, Japan

  • 2021 Ph.D.

    Graduate School of Medicine, Kyoto University, Kyoto, Japan

  • 2020

    Program-Specific Assistant Professor. Department of Pediatrics, Kyoto University Hospital, Kyoto, Japan

  • 2021

    Program-Specific Assistant Professor. Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan

I have been trained as a pediatrician and engaged in the clinical immunology research at Kyoto University from 2014. I have conducted genetic or functional analysis of the patients with inborn errors of immunity utilizing patient cells or patient-derived iPS cells. As a graduate student, I have described a novel disease concept; cell-type specific quantitative NEMO deficiency caused by a deep intronic mutation. After graduation, I have established an in vitro functional assay for the functional classification of MEFV variants to improve the accuracy of the diagnosis of Familial Mediterranean Fever (FMF).

From 2021, I have joined the Ueno group to further investigate human immunology. Now, my research topics are inborn errors of immunity (especially autoinflammatory diseases), allergy and pediatric rheumatology. I love 90’s J-POP.

Mio Hamatani M.D., Ph.D.

Mio Hamatani M.D., Ph.D.

Program-Specific Assistant Professor

  • 2010 M.D.

    Faculty of Medicine, Kyoto University, Kyoto, Japan

  • 2020 Ph.D.

    Graduate School of Medicine. Kyoto University, Kyoto, Japan

  • 2021

    Program-Specific Assistant Professor. Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan

Specific areas of focus include the pathology of neurological diseases and their relationship to the immune system.

Shusei Fujioka M.D.

Shusei Fujioka M.D.

Assistant Professor

  • 2017 M.D.

    Faculty of Medicine, Kyoto University, Kyoto, Japan

  • 2023

    Assistant Professor. Department of Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Bike enthusiast, dad of three. Studying human CD4+ T cell differentiation with mathematicians.Homepage

Mayu Fujioka M.D.

Mayu Fujioka M.D.

Assistant Professor

  • 2017 M.D.

    Faculty of Medicine, Kyoto University, Kyoto, Japan

  • 2023

    Assistant Professor. Department of Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Be a good scientist and a mom of three amazing children. My interest : B cell, feto-maternal crosstalk, something new and fun!

  • Ma Shuhe Ph.D.

    Program-Specific Researcher

    Shuhe Ma got her bachelor degree in Biotechnology at Harbin Institute of Technology (2014), and earned her master degree in Biology at Leiden university (2016). From 2017, she joined the doctoral course at the Graduate School of Medicine in Kyoto University, and undertook postdoctoral training at the Dept. of Immunology (2020-2021) as a postdoc. She obtained her Doctor degree at 2022. She joined ASHBi at April 2022.

  • Researcher

    I graduated from Kyoto Prefectural University of Medicine in 2013. I'm involved in clinical work with a focus on neuroimmunological diseases. Since 2020, I have been continuing my research in clinical immunology using patient blood and cerebrospinal fluid at the Ueno Lab.

  • Masaki Takata M.D.

    Doctoral (Ph.D.) student

  • Naila Shinwari

    Doctoral (Ph.D.) student

    Master’s from Quaid-e-Azam university Pakistan. I Joined this lab as COVID-19 researcher focusing on unraveling the mysteries of this pandemic. With a passion for science, I strive to understand how the virus spreads and contribute to the development of effective vaccines. Previous MEXT scholarship recipient. An awardee of ASHBi Financial Support Program for International Graduate Students.

  • Akinori Murakami M.D.

    Doctoral (Ph.D.) student

  • Hajime Morita M.D.

    Doctoral (Ph.D.) student

    I graduated from Kyoto University in 2014. I worked as a nephrologist and finished the nephrology fellowship in 2020. I am investigating liver resident T lymphocytes. I'm interested in the balance between tolerance and host defense in the liver. Recieving a scholarship (JPMJSP2110).

  • Yuya Shinoto M.D.

    Doctoral (Ph.D.) student

  • Toshiaki Bando M.D.

    Doctoral (Ph.D.) student

    I graduated from Faculty of Medicine at Nara Medical University in 2013. After working as a neurosurgeon for 6 years and obtaining a neurosurgeon specialist, I joined Ueno Lab in 2021 on the recommendation of my neurosurgeon boss. I am focusing on the interaction between liver hepatic stellate cells and immune cells in autoimmune liver disease, especially in primary biliary cholangitis.

  • Zhang Moyu

    Doctoral (Ph.D.) student

  • Rina Fujita M.D.

    Doctoral (Ph.D.) student

    I graduated from Hyogo College of Medicine in 2015. Following my clinical training, I enrolled in the doctoral course for neurology at Kyoto University in 2021. Since joining Ueno Lab in 2023, I have been conducting research on microglia using iPSCs.

  • Sari Hatanaka M.D.

    Doctoral (Ph.D.) student

    I graduated from Nara Medical University and worked as a pediatrician for five years. I am investigating immune cells, including T-cell subsets and basophils, which are involved in the pathogenesis of allergic diseases and the acquisition of tolerance. Recently, I have been interested in gardening and machine learning.

  • Mouna Khan

    Doctoral (Ph.D.) student

    I graduated as a Pharmacy Doctor in 2016, then specialized immunologist in 2021 from Algiers University. I worked as an immunology resident in Pasteur Institute of Algeria from 2016 to 2021, After that I joined Ueno Lab where I started my Doctoral course at the graduate school of Medicine in April 2022. I am interested in gamma-delta T cells in the liver. MEXT scholarship recipient.

  • Shunsuke Uno M.D.

    Doctoral (Ph.D.) student

    I am a board-certified pathologist in Japan. Currently, I am engaged in research on single-cell spatial transcriptomics in liver diseases.

  • Rinko Akamine M.D.

    Doctoral (Ph.D.) student

    Interested in autoimmune disease, especially rheumatoid arthritis. Love travel to the islands. Recieving "Kibou" Project scholarship (from Japanese Society for Immunology).

  • Yuki Masuo M.D.

    Doctoral (Ph.D.) student

    I graduated from Faculty of Medicine at Kyoto University in 2018. After residency, I worked as a hematologist for 2 years, when I treated patients with hematological malignancies and autoimmune diseases. Close relationship between these diseases and immunology prompted me to join the research in this field. I am currently focusing on cancer immunology and vaccine response in humans. Recieving a scholarship from Takeda Science Foundation.

  • Daichi Akuzawa M.D.

    Doctoral (Ph.D.) student

    I graduated from Shiga University of Medical Science in 2017. After working as a pediatrician, I started research in the Graduate School of Medicine at Kyoto University from 2022. I am focusing on the interaction between cholangiocytes , hepatocytes and immune cells especially in primary biliary cholangitis and hepatitis B by using the human liver organoid model. JSPS DC1 scholarship recipient.

  • Xue Xinxin

    Doctoral (Ph.D.) student

    I am Xinxin Xue. I graduated from McGill University with a Bachelor's degree in Life Sciences from the Faculty of Agricultural and Environmental Science. I joined Ueno Lab in 2021 and obtained a Master’s degree in Medical Science in March 2023. Currently, I am a Ph.D. student specializing in COVID-19 vaccine studies. An awardee of ASHBi Financial Support Program for International Graduate Students.

  • Hirotaka Sato M.D.

    Doctoral (Ph.D.) student

  • Lynn Zreka M.D.

    Master student

    I graduated from Tishreen University, school of medicine in 2019 in Syria.Joined Ueno Lab in 2020 October as a research student for 1 year and half.And now, I am a first year master student, working on analyzing granulocytes residing in liver. My dream is to find some treatment to Autoimmune Hepatitis (AIH) in the future. MEXT scholarship recipient.

  • Chua Celine

    Master student

    I graduated from the National University of Singapore in 2022 with honours in Biomedical Science. Since 2020, I was attached to Agency for Science, Technology and Research (A*STAR) where I focused on the characterisation of immune responses underlying allergic diseases. Joining Ueno Lab in 2023 to further my interest in immunology, I am currently working on elucidating immune responses in infectious diseases and vaccine immunity. MEXT scholarship recipient.

  • Zhang Yunni M.D.

    Researcher

    Graduated as Medical Doctor eight-year program from West China School of Medicine, Sichuan University in 2018. Worked as a urology surgeon from 2018 to 2022 at Xiamen University Hospital. Joined Ueno lab as foreign co-researcher in 2022 May. Interested in tumor immunological microenvironment and immunotherapy in urological cancer.

  • Lu Dongyun

    Researcher

    I graduated from Shanghai Jiao Tong University in 2022, majoring in Biotechnology. With a great interest in infectious diseases, especially COVID-19, I hope to become a researcher with good scientific literacy in Ueno Lab. Currently, I decided to spend one year as a Research Student, learning experiment techniques and enhancing my theoretical knowledge basement.

  • Ryo Nishida

    Undergraduate student

  • Joey Matsuyama

    Undergraduate student

  • Natsumi Iwasaki

    Technical staff

  • Chihiro Nishino

    Technical staff

  • Emi Onohara

    Technical staff

  • Aki Mitsunaka

    Technical staff

  • Ketevan Janashvili

    Technical staff

  • Mami Fujita

    Secretary

  • Nana Sugie

    Secretary

  • Ryutaro Ariyama

    Faculty of Medicine

  • Hodaka Ishibashi

    Faculty of Medicine

  • Kazuki Oga

    Faculty of Medicine

  • Shin Yanagisawa

    Faculty of Medicine

  • Chimomo Nakajima

    Faculty of Medicine

  • Shota Tokonami

    Faculty of Medicine

  • Takashi Ota

    Faculty of Medicine

  • Sakurako Inoue

    Faculty of Medicine

  • Ryo Kato

    Faculty of Medicine

  • Fumiya Kondo

    Faculty of Medicine

Past Members

  • Chiyomi Sasaki

    Researcher

  • Yayoi Iwamoto

    Staff

  • Kenji Okuma

    Researcher

  • Kensuke Nishioka

    Researcher